李 娜

博士,教授,博士生导师

分析化学

电话:010-62761187   传真:62751708
电子信箱: lina@pku.edu.cn

学习工作经历

  • 1988、 1991 和 1994 年先后获kaiyun体育官方网站理学学士、硕士和博士学位
  • 1994-1998 年,kaiyun体育官方网站化学公司工作
  • 1999-2000,美国堪萨斯大学 药化系 CDDR 博士后
  • 2000至今 kaiyun体育官方网站化学公司工作

教学:

主讲定量化学分析(中文班和英文班)
主讲分析化学系列小班讨论课
获2008年北京市教育教学成果一等奖。
2011年北京市高等教育精品教材
2016年教育部来华留学英语授课品牌课程
2020年北京市优质本科课程(重点课程)

出版教材:

  1. 分析化学——定量化学分析简明教程(第4版),kaiyun体育官方网站出版社,2020(主编)
  2. Quantitative Chemical Analysis(英文). kaiyun体育官方网站出版社,2009 (主编)
    (海外发行World Scientific Publishing Co Pte Ltd, 2013)
  3. 分析化学I(电子课件). kaiyun体育官方网站出版社, 2007(主编)
  4. 仪器分析教程(第3版). kaiyun体育官方网站出版社, 2021 (参编)
  5. 分析化学教程学习指导. kaiyun体育官方网站出版社, 2006 (参编)
  6. 分析化学教程 . kaiyun体育官方网站出版社, 2005 (参编)
  7. 超越分子前沿.科学出版社,2004 (参译)

研究领域和兴趣:

光学传感新原理、新方法。主要兴趣为:
基于金属纳米材料光谱(荧光、局域表面等离子体共振吸收/散射)的生物传感。

2012年以来发表的主要学术论文:

  1. Rong Sheng Li, Jiahui Liu, Cong Wen, Yaru Shi, Jian Ling, Qiue Cao, Lei Wang, Hu Shi*, Cheng Zhi Huang*, Na Li*
    Transformable Nano-Antibiotics for Mechanotherapy and Immune Activation against Drug-Resistant Gram-Negative Bacteria
    Sci. Adv. 2023, 9 (34), eadg9601.
  2. Rongsheng Li, Cong Wen, Chengzhi Huang*, Na Li*
    Functional Molecules and Nano-materials for the Golgi Apparatus-Targeted Imaging and Therapy
    TRAC-Trend. Anal. Chem. 2022, 156(15), 116714.
  3. Xi Wu, Rongsheng Li, Tiancheng Lai, Guangyu Tao, Feng Liu, Na Li*
    A Universal Nanoparticle Counting Platform for Tetraplexed Biomarkers by Integrating Immuno-recognition and Nucleic Acid Hybridization in One Assay
    Anal. Chem. 2021, 94, 1687316879.
  4. Rong Sheng Li, Jia Hui Liu, Hu Shi*, Ping Ping Hu, Yao Wang, Peng Fei Gao, Jian Wang, Moye Jia, Hongwei Li, Yuan Fang Li, Chengde Mao*, Na Li*, Cheng Zhi Huang*
    Transformable Helical Self-Assembly for Cancerous Golgi Apparatus Disruption.
    Nano Lett. 2021, 21 (19), 8455–8465
  5. Rongsheng Li, Jiahui Liu, Yuan Yan, Chuanyang Su, Tiancheng Lai, Yunwen Liao, Yuan Fang Li, Na Li*, Cheng Zhi Huang*
    Aggregation-Enhanced Energy Transfer for Mitochondria-Targeted ATP Ratiometric Imaging in Living Cells.
    Anal. Chem. 2021, 93 (34), 11878–11886
  6. Guangyu Tao, Xiao Xu, Rong Sheng Li, Feng Liu, and Na Li*
    Nonamplification Multiplexed Assay of Endonucleases and DNA Methyltransferases by Colocalized Particle Counting
    ACS Sens., 2021, 6, 1321–1329
  7. Guangyu Tao, Tiancheng Lai, Xiao Xu, Yurou Ma, Xi Wu, Xiaojing Peo, Feng Liu, Na Li*
    Colocalized Particle Counting Platform for Zeptomole Level Multiplexed Quantification
    Anal. Chem., 2020, 92, 3697–3706
  8. Tian Li, Xi Wu, Guangyu Tao, Haoyan Yin, Junlong Zhang, Feng Liu, Na Li*
    A simple and non-amplification platform for femtomolar DNA and microRNA detection by combining automatic gold nanoparticle enumeration with target-induced strand-displacement
    Biosens. Bioelectron. 2018, 105, 137–142.
  9. Xiaojing Pei, Tiancheng Lai, Guangyu Tao, Hu Hong, Feng Liu, and Na Li*
    Ultra-specific multiplexed detection of low-abundance single-nucleotide variants by combining masking tactic with fluorescent nanoparticle counting
    Anal. Chem., 2018, 90, 4226–4233
  10. Xiaojing Pei, Haoyan Yin, Tiancheng Lai, Junlong Zhang, Feng Liu, Xiao Xu*, Na Li*
    Multiplexed Detection of Attomole Nucleic Acids Using Fluorescent Nanoparticle Counting Platform
    Anal. Chem., 2018, 90, 1376–1383
  11. Guangyu Tao, Yang Chen, Ruoyun Lin, Jiang Zhou, Xiaojing Pei, Feng Liu, Na Li
    How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters
    Nano Res. 2017, 11, 223–2247
  12. Ruoyun Lin, Guangyu Tao, Yang Chen, Mingxing Chen, Feng Liu, and Na Li*.
    Constructing a robust fluorescent DNA-stabilized silver nanocluster probe module by attaching a duplex moiety
    Chem. Eur. J., 2017, 23, 10893–10900
  13. Runyun Lin, Chenxi Li, Yang Chen,.Feng Liu, and Na Li*
    Metal-enhanced fluorescence in biosensing applications, "Surface Plasmon Enhanced, Coupled and Controlled Fluorescence", 2017, Edited by Geddes, C. D., Wiley, NJ. (Invited chapter)
  14. Tian Li, Xiao Xu, Guoqing Zhang, Ruoyun Lin, Yang Chen, Chenxi Li, Feng Liu, and Na Li*
    'Nonamplification Sandwich Assay Platform for Sensitive Nucleic Acid Detection Based on Aunps Enumeration with the Dark-Field Microscope
    Anal. Chem., 2016, 88, 4188–91.
  15. Xiao Xu, tian Li, Zhongxing Xu, Hejia Wei, Ruoyun Lin, Bin Xia, Feng Liu, Na Li*
    Automatic enumeration of gold nanomaterials at single particle level.
    Anal. Chem. 2015, 87, 2576–2581
  16. Hongduan Huang, Hejia Wei, Mingjian Zou, Xiao Xu,Bin Xia*, Feng Liu, Na Li*
    Modulating fluorescence anisotropy of terminally labeled dsDNA via the interaction between dye and nucleotides for rational design of DNA-recognition based applications.
    Anal. Chem. 2015, 87, 2748–2754
  17. Zhenpeng Zhou, Tian Li, Hongduan Huang, Yang Chen, Feng Liu, Chengzhi Huang,* and Na Li*
    A dual amplification strategy for DNA detection combining bio-barcode assay and metal-enhanced fluorescence modality
    Chem. Commun., 2014, 50, 13373–13376
  18. Chenxi Li, Yixin Li, Xiao Xu, Xinyi Wang, Yang Chen, Xiaoda Yang, Feng Liu, and Na Li*
    Fast and quantitative differentiation of single-base mismatched DNA by initial reaction rate of catalytic hairpin assembly.
    Biosens. Bioelectron. 2014, 60, 57–63.
  19. Zhenpeng Zhou, Hongduan Huang, Yang Chen, Feng Liu, Chengzhi Huang, Na Li*
    A distance-dependent metal-enhanced fluorescence sensing platform based on molecular beacon design
    Biosens. Bioelectron. 2014, 52, 367–373
  20. Xinyi Wang, Mingjian Zou, Hongduan Huang, Yuqian Ren, Limei Li, Xiaoda Yang, Na Li*
    Gold nanoparticle enhanced fluorescence anisotropy for the assay of single nucleotide polymorphisms (SNPs) based on toehold-mediated strand-displacement reaction
    Biosens. Bioelectron. 2013, 41, 569–575
  21. Xiao Xu, Yang Chen, Hejia Wei, Bin Xia, Feng Liu and Na Li*
    Counting Bacteria Using Functionalized Gold Nanoparticles as the Light-Scattering Reporter
    Anal. Chem. 2012, 84, 9721–9728.
  22. Mingjian Zou, Yang Chen, Xiao Xu, Hongduan Huang, Feng Liu, Na Li*
    The homogeneous Fluorescence Anisotropic Sensing of Salivary Lysozyme Using the 6-carboxyfluorescein-labeled DNA Aptamer
    Biosens. Bioelectron. 2012, 32, 148–154
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